COMORBIDITY AS A FACTOR OF GASTRODUODENAL ULCER DEVELOPMENT IN ELDERLY AND SENILE PATIENTS

Introduction. Peptic ulcer disease is a chronic recurrent multifactorial disease that takes its course with alternating exacerbations and remissions and is manifested by ulcerative defects in the mucous membrane of the stomach and duodenum, which is based on an imbalance of aggressive and protective factors with a predominance of ВЕСТНИК СОВРЕМЕННОЙ КЛИНИЧЕСКОЙ МЕДИЦИНЫ 2024 Том 17, вып. 6 85ОБЗОРЫ the former ones. Of particular interest is the comparative characteristics of gastric and duodenal ulcers in the patients of senile and elderly age groups due to their pathogenetic features and singularity of their clinical picture. Aim. The aim of the study was to summarize current data on the impact of comorbid pathology on the course of gastric and duodenal ulcers in elderly and senile patients. Materials and Methods. Current studies were reviewed, published in the eLibrary, Scopus, and PubMed databases in 2014–2024and appearing in Google Scolar, dealing with the etiopathogenetic variants of gastric and duodenal ulcers and comorbidity with various diseases in elderly and senile patients. Results and Discussion. The increase in numbers of patients with peptic ulcer disease among those in the elderly and senile age groups takes place due to the global demographic aging of the population, which leads to an increase in numbers of patients with multiple chronic diseases. In most cases, in elderly and senile patients, peptic ulcers of the stomach and duodenum are not any evidence of a distinct disease entity known as peptic ulcer disease. Among such patients, peptic ulcer is a multifactorial disease of polyetiological origin with many etiopathogenetic variants, including various changes associated with cardiovascular diseases, such as atherosclerosis, coronary heart disease, and chronic heart failure; endocrine pathologies; and concomitant peptic ulcers in the chronic diseases of lungs or kidneys and post-coronavirus metabolic disorders. Of particular interest are the so-called drug-induced ulcers associated with the treatment of a chronic or acute disease and providing an ulcerogenic effect on the stomach and duodenum. Conclusions. Taking into account the data obtained on the etiopathogenetic variants of peptic ulcer disease, the task was set to study the prevalence of gastric and duodenal ulcers among elderly and senile patients with chronic diseases. Timely identification of the comorbid nature of the disease will allow achieving better results in therapy and improve the prognosis of patients with gastric and duodenal ulcers.