Integrated machine learning reveals the role of tryptophan metabolism in clear cell renal cell carcinoma and its association with patient prognosis
This study investigated the potential impact of dysregulated tryptophan metabolism on clear cell renal cell carcinoma, leading to the development of a tryptophan metabolism-related signature that may provide insights into patient prognosis, tumor biological status, and personalized treatment strategies. This signature serves as a valuable reference for further exploring the role of tryptophan metabolism in renal cell carcinoma and for the development of clinical applications based on this metabolic pathway.
Authors
- Xianjiong Chen (ORCID: https://orcid.org/0009-0009-2419-0885)
- Yi Lu (ORCID: https://orcid.org/0000-0001-9933-3654)
- Liyang Li (ORCID: https://orcid.org/0000-0003-1107-4155)
- Yudong Lin (ORCID: https://orcid.org/0000-0002-9881-9561)
- Liqun Xia (ORCID: https://orcid.org/0000-0001-5040-4992)
- Zeyi Lu
- Gonghui Li (ORCID: https://orcid.org/0000-0001-9845-7241)
- Xudong Mao
- Wenqin Luo (ORCID: https://orcid.org/0000-0002-2486-807X)
- Chenhao Zhou (ORCID: https://orcid.org/0000-0002-4800-3249)
- Lifeng Ding (ORCID: https://orcid.org/0000-0002-1145-9584)
- Ziwei Zhu (ORCID: https://orcid.org/0000-0001-6423-9553)
- Fan Li (ORCID: https://orcid.org/0000-0003-3550-0243)
- Yang Li (ORCID: https://orcid.org/0000-0002-7677-9028)
- Lei Gao (ORCID: https://orcid.org/0000-0002-3897-6362)
- Ruyue Wang (ORCID: https://orcid.org/0000-0003-2276-0214)
- Haiyi Hu
- Mingchao Wang
Institutions
- Sir Run Run Shaw Hospital (CN)
- UNSW Sydney (AU)
- Zhejiang University (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2024-12-21
- DOI
- https://doi.org/10.1186/s13062-024-00576-w
- Citations
- 9
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.77
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province