Preparation and evaluation of bio-adhesive dosage form of chlorhexidine gluconate

This research investigates the development and optimization of a novel mucoadhesive buccal film containing chlorhexidine gluconate for enhanced oral health. The introduction highlights the prevalence of oral afflictions and the limitations of conventional oral medications. Mucoadhesive dosage forms are presented as a promising alternative, offering targeted drug delivery and improved therapeutic efficacy. The sections delve into the concept of mucosal dosage forms, explaining their mechanism of action and various applications. The advantages and challenges associated with this delivery system are also discussed. The methodology outlines the materials and processes involved in formulation the chlorhexidine-loaded the film. The experimental design details the evaluation parameters employed to assess the films quality, including weight uniformity, thickness, surface pH, swelling index, folding endurances, drug content, mucoadhesion, anti-inflammatory activity, moisture loss, in-vitro drug release, anti-microbial activity, and surface morphology using scanning electron microscopy. Overall, this research aims to develop a bio-adhesive buccal film loaded with chlorhexidine gluconate to provide sustained and localizes antimicrobial activity in the oral cavity, potentially improving oral health outcome.