M6A modification-mediated LIMA1 promotes the progression of hepatocellular carcinoma through the wnt-βcatenin/Hippo pathway
In HCC, LIMA1 functions as a tumor promoter and engages with the WNT-β-catenin and Hippo signaling pathways,, affecting the characteristics of tumor cells. LIMA1 expression is regulated by METTL3-mediated m6A modification, leading to its high expression in HCC. Our research presents a hopeful objective for the detection and therapy of HCC.
Authors
- Yiran Yuan
- Huangqin Song (ORCID: https://orcid.org/0000-0002-4190-8424)
- Junlong Yuan
- Zhuangqiang Wang
- Xiaomin Zhang (ORCID: https://orcid.org/0000-0003-3877-5242)
- Chao Zhang
- Jiefeng He
- Lei Zhang (ORCID: https://orcid.org/0000-0002-5768-4840)
- Xiaoxiao Wang (ORCID: https://orcid.org/0000-0001-7585-5925)
Institutions
- Shanxi Medical University (CN)
- Xian Central Hospital (CN)
- Shanxi Academy of Medical Sciences (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cell Biology and Toxicology
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1007/s10565-024-09959-1
- Citations
- 7
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.64
Funders
- National Natural Science Foundation of China