A Novel Multi-organ Male Model of Alcohol-induced Acute-on-chronic Liver Failure Reveals NET-mediated Hepatocellular Death, Which is Prevented by RIPK3 Inhibition
Our novel ACLF model triggered by alcohol binge mimics key features of pathophysiology and multi-organ impairment in human ACLF. Our results indicate that neutrophil infiltration and NETs contribute to hepatocyte cell death via pyroptosis and necroptosis in ACLF, identifying RIPK3 as a potential therapeutic target.
Authors
- Gyöngyi Szabó (ORCID: https://orcid.org/0000-0003-0836-2527)
- Veronika Brezáni (ORCID: https://orcid.org/0000-0003-2980-6334)
- Yanbo Wang (ORCID: https://orcid.org/0000-0003-4052-6421)
- Mrigya Babuta (ORCID: https://orcid.org/0000-0001-8420-4796)
- Prashanth Thevkar Nagesh (ORCID: https://orcid.org/0000-0001-9928-9905)
- Zsuzsanna K. Zsengellér (ORCID: https://orcid.org/0000-0002-4540-5728)
- Martí Ortega‐Ribera (ORCID: https://orcid.org/0000-0001-8647-7069)
- Roderick T. Bronson (ORCID: https://orcid.org/0000-0003-3725-2511)
- Yuan Zhuang (ORCID: https://orcid.org/0000-0001-8521-5032)
- Radhika Joshi (ORCID: https://orcid.org/0000-0002-4313-2586)
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1016/j.jcmgh.2024.101446
- Citations
- 12
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.64
Funders
- National Institutes of Health