Effects of ALA-PDT on the murine footpad model of Fonsecaea monophora infection and its related mechanisms in vivo
ALA-PDT demonstrated fungicidal effects in a mouse footpad infection model with F. monophora and attenuated the inflammatory reactions. It may also assist against the intracellular fungi by the host through macrophage receptor MARCO and regulation of the immune microenvironment. This study provides scientific evidence for the protocol selection of ALA-PDT as a promising adjunctive modality for treating chromoblastomycosis.
Authors
- Yongxuan Hu (ORCID: https://orcid.org/0000-0001-7286-7584)
- Kangxing Liu
- Yanqing Hu (ORCID: https://orcid.org/0000-0003-0653-0259)
- Xuelin Wu
- Lu Yan (ORCID: https://orcid.org/0009-0009-6050-4909)
- Wenyi Chen
- Muhammad Danish Yaqoob
Institutions
- Third Affiliated Hospital of Southern Medical University (CN)
Publication Details
- Journal
- Photodiagnosis and Photodynamic Therapy
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1016/j.pdpdt.2024.104452
- Citations
- 4
- Primary Topic
- Parasitic infections in humans and animals
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- Natural Science Foundation of Guangdong Province