FDFT1 maintains glioblastoma stem cells through activation of the Akt pathway
GSCs exhibit a dependency on FDFT1-mediated mevalonate metabolism. Inhibition of FDFT1 could represent a potent strategy to eliminate GSCs.
Authors
- Peiting Zeng (ORCID: https://orcid.org/0000-0001-9615-5653)
- Jiajia Shao (ORCID: https://orcid.org/0000-0001-6364-2500)
- Peng Wang (ORCID: https://orcid.org/0000-0001-6294-2085)
- Hui Mo (ORCID: https://orcid.org/0000-0001-5415-2788)
- Yongsheng Huang (ORCID: https://orcid.org/0009-0007-1861-7489)
- Jianwei Liao (ORCID: https://orcid.org/0000-0002-2704-8659)
- Xinke Yin
- Zhun Li (ORCID: https://orcid.org/0000-0003-2646-9897)
Institutions
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Foshan Second People's Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s13287-024-04102-7
- Citations
- 6
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- National Natural Science Foundation of China
- Guangzhou Municipal Science and Technology Project
- Basic and Applied Basic Research Foundation of Guangdong Province