Single-cell analysis reveals the loss of FABP4-positive proliferating valvular endothelial cells relates to functional mitral regurgitation
Our study presented a comprehensive assessment of the mitral valve cellular landscape of patients with MR and sheds light on the molecular changes occurring in human mitral valves during functional MR. We found a notable reduction in the proliferating endothelial cell subpopulation of valve leaflets, and FABP4 was identified as one of their markers. Therefore, FABP4 positive VECs served as proliferating endothelial cells relates to functional mitral regurgitation. These VECs exhibited high proliferative and differentiative properties. Their reduction was associated with the occurrence of functional MR.
Authors
- Xiumeng Hua (ORCID: https://orcid.org/0009-0006-5424-8812)
- Weiteng Wang (ORCID: https://orcid.org/0000-0001-6480-9325)
- Jiangping Song
- Mengxia Fu (ORCID: https://orcid.org/0000-0002-6286-9233)
- Ruojin Zhao
- Songren Shu (ORCID: https://orcid.org/0000-0001-8659-197X)
- Xin Wang (ORCID: https://orcid.org/0000-0002-0922-0718)
- Ningning Zhang (ORCID: https://orcid.org/0000-0001-6744-3867)
- Xiaohu Wang (ORCID: https://orcid.org/0009-0005-0876-3680)
- Chen Xiao (ORCID: https://orcid.org/0000-0002-0287-8330)
- Xianqiang Wang (ORCID: https://orcid.org/0000-0003-0602-6765)
- Wei Feng (ORCID: https://orcid.org/0009-0009-5385-5831)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Kunming Medical University (CN)
- Fuwai Yunnan Cardiovascular Hospital (CN)
- Beijing Shijitan Hospital (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s12916-024-03791-4
- Citations
- 2
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Science Foundation
- National Natural Science Foundation of China
- Science, Technology and Innovation Commission of Shenzhen Municipality
- National Science Fund for Distinguished Young Scholars