Effect of IV Thrombolysis With Alteplase in Patients With Vessel Occlusion in the WAKE-UP Trial
This study provides Class II evidence that for patients with unknown-onset ischemic stroke with AVO, MRI-guided treatment with IV tissue plasminogen activator improves outcomes.
Authors
- Matthias Endres (ORCID: https://orcid.org/0000-0001-6520-3720)
- Götz Thomalla (ORCID: https://orcid.org/0000-0002-4785-1449)
- Robin Lemmens (ORCID: https://orcid.org/0000-0002-4948-5956)
- Salvador Pedraza (ORCID: https://orcid.org/0000-0003-2517-4413)
- Christian Enzinger (ORCID: https://orcid.org/0000-0001-9764-7617)
- Bastian Cheng (ORCID: https://orcid.org/0000-0003-2434-1822)
- Johannes Gregori (ORCID: https://orcid.org/0000-0002-8651-164X)
- Vincent Thijs (ORCID: https://orcid.org/0000-0002-6614-8417)
- Keith W. Muir (ORCID: https://orcid.org/0000-0001-9535-022X)
- Anke Wouters (ORCID: https://orcid.org/0000-0001-5229-2699)
- Tae‐Hee Cho (ORCID: https://orcid.org/0000-0001-8677-2447)
- Pascal Roy (ORCID: https://orcid.org/0000-0003-3837-3198)
- Jens Fiehler (ORCID: https://orcid.org/0000-0001-8533-7478)
- Martin Ebinger (ORCID: https://orcid.org/0000-0002-5073-4665)
- Ivana Galinović (ORCID: https://orcid.org/0000-0003-4904-8251)
- Christian Gerloff (ORCID: https://orcid.org/0000-0002-6484-8882)
- Jochen B. Fiebach (ORCID: https://orcid.org/0000-0002-7936-6958)
- Ian Ford
- Norbert Nighoghossian
- Claus Z. Simonsen (ORCID: https://orcid.org/0000-0003-1363-0266)
- Florent Boutitie
- Matthias Günther (ORCID: https://orcid.org/0000-0002-2650-7956)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Universität Hamburg (DE)
- Hospices Civils de Lyon (FR)
- University Medical Center Hamburg-Eppendorf (DE)
Publication Details
- Journal
- Neurology
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1212/wnl.0000000000209871
- Citations
- 5
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- European Commission
- Universitätsklinikum Hamburg-Eppendorf