Synthesis of Nitrones Based on Triterpenes C<sup>3</i>-Hydroxylamines of the Lupane Series
An approach was developed to the synthesis of triterpene C3-nitrones containing the amide function at C28-position, new derivatives of pentacyclic triterpenoids of the lupan series. Diastereomeric triterpene 3β- and 3α-hydroxylamines obtained by reduction of oxime based on betulonic acid isopropylamide with NaBH3CN in a solution of 2 M HCl in MeOH were used as starting compounds. Nitrones were synthesized by condensation of hydroxylamines with substituted benzaldehydes in dichloromethane in the presence of Na2SO4.
Authors
- Л. В. Спирихин (ORCID: https://orcid.org/0000-0002-3163-882X)
- N. G. Komissarova (ORCID: https://orcid.org/0000-0002-7571-1232)
- A. V. Orlov (ORCID: https://orcid.org/0000-0001-6145-3343)
Institutions
- Ufa Institute of Chemistry (RU)
Publication Details
- Journal
- Журнал Общей Химии
- Published
- 2024-12-20
- DOI
- https://doi.org/10.31857/s0044460x24070022
- Citations
- 1
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.23