Targeting PTGDS Promotes ferroptosis in peripheral T cell lymphoma through regulating HMOX1-mediated iron metabolism
Taken together, our findings firstly identified that targeting PTGDS promotes the ferroptosis in PTCL through regulating HMOX1-mediated iron metabolism, and highlighted novel therapeutic strategies to improve the efficacy of ferroptosis-targeted therapy in PTCL patients.
Authors
- Xiangxiang Zhou (ORCID: https://orcid.org/0000-0003-0725-716X)
- Shunfeng Hu (ORCID: https://orcid.org/0000-0002-6893-7065)
- Qianqian Guo (ORCID: https://orcid.org/0009-0006-9145-7576)
- Xiaoli Zhou (ORCID: https://orcid.org/0000-0002-3096-3911)
- Juanjuan Shang (ORCID: https://orcid.org/0009-0005-9586-9650)
- Xin Wang (ORCID: https://orcid.org/0000-0001-8051-1481)
- Bingyu Liu (ORCID: https://orcid.org/0000-0003-4817-5355)
- Tiange Lu
Institutions
- Shandong University (CN)
- Soochow University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Shandong Provincial Hospital (CN)
- Taishan University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1038/s41416-024-02919-w
- Citations
- 12
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 5.03
Funders
- China Postdoctoral Science Foundation
- Natural Science Foundation of Shandong Province
- Shandong First Medical University
- Key Technology Research and Development Program of Shandong