Dysregulation of Brain Cholesterol Biosynthetic Pathway following Hypoxia Ischemia in Neonatal Mice
Our data suggest perturbed brain cholesterol biosynthesis following neonatal HI. As some sterol intermediates and enzymes have diverse functions in brain development and stress responses other than producing cholesterol, assessment of their dynamic changes after HI is important to understand the lipid responses in rodent HI models and to identify lipid-based targeted therapies in future studies.
Authors
- Donna M. Ferriero (ORCID: https://orcid.org/0000-0003-0560-9045)
- Jeffrey G. McDonald (ORCID: https://orcid.org/0000-0003-1570-4142)
- Tiina Manninen (ORCID: https://orcid.org/0000-0002-0456-1185)
- Congshan Zhu
- Chase D. Corley (ORCID: https://orcid.org/0000-0002-5638-9620)
- Xiangning Jiang
- Fuxin Lu
- C-L Yen
- Nicholas R. Stewart
Institutions
- University of California, Riverside (US)
- Tampere University (FI)
- University of California, San Francisco (US)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Developmental Neuroscience
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1159/000543254
- Citations
- 1
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.57