Copper-Catalyzed Regioselective Annulation of β-Keto Esters and Propargyl Acetates: Access to Polysubstituted Furans
A copper-catalyzed regioselective annulation reaction, conducted without ligands or oxidants, has been developed for the preparation of multisubstituted furans from the readily available starting materials, β-keto esters and propargyl acetates. This process accommodates a wide range of functional groups, resulting in furan skeletons with diverse substitution patterns. The method's potential synthetic utility is highlighted by its applicability in gram-scale preparations and late-stage modifications of natural products.
Authors
- Yuzhu Yang (ORCID: https://orcid.org/0000-0002-9505-7952)
- Fei Li (ORCID: https://orcid.org/0000-0001-9822-7526)
- Hongke Xu (ORCID: https://orcid.org/0000-0001-5676-1683)
- Yuchen Yang (ORCID: https://orcid.org/0000-0002-7124-5924)
Institutions
- Guiyang Medical University (CN)
- Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1021/acs.joc.4c02408
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- West Light Foundation of the Chinese Academy of Sciences
- State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University