Nano-medicinal potential of Himalayan mushroom - Ganoderma lucidium

The medicinal mushroom Ganoderma lucidium reportedly possesses a variety of advantageous properties. Due to its rare existence in nature, people primarily cultivate this traditional Chinese medicinal mushroom on wood logs and sawdust in plastic bags or bottles. G. lucidium exhibits a wide range of biological effects, including anticancer, antidiabetic, and antibacterial properties. The extract and its active components have led to the development of numerous nutraceuticals and medicines. By preventing and treating a wide range of ailments, these formulations prolong life and improve health. Researchers are extensively studying metallic nanoparticles, particularly silver nanoparticles (AgNPs), created by bioengineered sources in the search for new anti-infective drugs. The current study showcased the production of colloidal AgNPs from G. lucidium at different temperatures, as measured by zeta potential, particle size analyzer, UV-spectrophotometry, and FTIR. Furthermore, the agar well diffusion assay and MIC test depicted antimicrobial activity against Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa. The nanoformulation of G. lucidium could have potential applications, particularly as an antimicrobial agent in food, pharmaceuticals, and cosmetic products, which could aid in preventing microbial infection.