Tracing carriage, acquisition, and transmission of ESBL-producing Escherichia coli over two years in a tertiary care hospital
Our data show a high prevalence of nosocomial acquisition of ESBL-E in a non-ICU setting. The study provides genomic evidence that the endogenous reservoir is the main driver of ESBL-Ec infections underscoring the need for wide implementation of antibiotic stewardship programmes to reduce antibiotic pressure.
Authors
- Y. Glupczynski (ORCID: https://orcid.org/0000-0002-9419-6387)
- Basil Britto Xavier (ORCID: https://orcid.org/0000-0002-5897-0240)
- Herman Goossens (ORCID: https://orcid.org/0000-0003-4891-4031)
- Sandra Van Puyvelde (ORCID: https://orcid.org/0000-0001-8434-5732)
- Qiang Lin (ORCID: https://orcid.org/0000-0001-8315-3464)
- Roberto Cauda
- Yehuda Carmeli
- Christine Lammens (ORCID: https://orcid.org/0000-0001-9424-3107)
- Liliana Preoțescu (ORCID: https://orcid.org/0000-0002-3328-4789)
- Silvia Venturiello
- Beryl Primrose Gladstone (ORCID: https://orcid.org/0000-0002-4733-5890)
- Surbhi Malhotra‐Kumar (ORCID: https://orcid.org/0000-0001-8699-8905)
- Stephan Harbarth (ORCID: https://orcid.org/0000-0002-3551-1025)
- Evelina Tacconelli (ORCID: https://orcid.org/0000-0003-2010-4977)
- Mona Popoiu
- S. Cohen Percia
- Amos Adler (ORCID: https://orcid.org/0000-0003-2957-9741)
- Giovanni Restuccia
- Giulia De Angelis (ORCID: https://orcid.org/0000-0002-7087-7399)
- Michael Biggel (ORCID: https://orcid.org/0000-0002-1337-2132)
- Biljana Carević
- Tanja Tošić
- Samir Kumar‐Singh (ORCID: https://orcid.org/0000-0001-9466-6732)
- Jacques Schrenzel (ORCID: https://orcid.org/0000-0001-5464-7764)
- Minh Ngoc Nguyen (ORCID: https://orcid.org/0000-0001-7652-1898)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- University of Verona (IT)
- University Medical Center Groningen (NL)
- University of Antwerp (BE)
- University of Zurich (CH)
- Tel Aviv Sourasky Medical Center (IL)
- Agostino Gemelli University Polyclinic (IT)
- Infectious Diseases Institute (UG)
- University Children's Hospital Tübingen (DE)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Tübingen (DE)
Publication Details
- Journal
- Genome Medicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s13073-024-01424-2
- Citations
- 4
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.68
Funders
- Vlaamse Overheid
- Fonds Wetenschappelijk Onderzoek
- FP7 Health