Eplerenone, a mineralocorticoid receptor inhibitor, reduces cirrhosis associated changes of hepatocyte glucose and lipid metabolism
Our findings suggest that non-physiological MR activation plays a role in the dysregulation of glucose and lipid metabolism in hepatocytes. This leads to an increase in apoptosis, probably resulting in a proinflammatory micromilieu of the hepatic tissue. The enhanced deposition of extracellular matrix contributes to the development of cirrhosis. Therefore, MR antagonists may have therapeutic potential in the treatment of early stages of liver disease due to their direct action in the liver.
Authors
- Alexander Nolze (ORCID: https://orcid.org/0000-0003-3701-2155)
- Sindy Rabe
- Alexander Zipprich (ORCID: https://orcid.org/0000-0001-8403-7983)
- Michael Gekle (ORCID: https://orcid.org/0000-0002-1581-8767)
- Mohammad Mohabbulla Mohib (ORCID: https://orcid.org/0000-0002-7910-7147)
- Barbara Schreier (ORCID: https://orcid.org/0000-0002-3087-6439)
- Quratul Ain
- Michael Rooney
Institutions
- Jena University Hospital (DE)
- University Hospital in Halle (DE)
- Martin Luther University Halle-Wittenberg (DE)
- Friedrich Schiller University Jena (DE)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s12964-024-01991-2
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Deutsche Forschungsgemeinschaft