Biological brain age and resilience in cognitively unimpaired 70‐year‐old individuals
BAG, reflecting deviations from CA, can indicate resilience. Diabetes, stroke, and low physical activity link to "older" brains (greater BAG). Physical activity yielded to "younger" brains in septuagenarians with obesity. High cerebrovascular burden, inflammation, and glucose associate with "older" brains. Sex differences were detected in all BAG-associated factors.
Authors
- Sara Shams (ORCID: https://orcid.org/0000-0002-5133-0224)
- Olof E. Lindberg (ORCID: https://orcid.org/0000-0001-6352-108X)
- Anna Zettergren (ORCID: https://orcid.org/0000-0002-7182-8417)
- Caroline Machado Dartora (ORCID: https://orcid.org/0000-0003-1357-3230)
- Ingmar Gr. Skoog (ORCID: https://orcid.org/0000-0002-9803-3438)
- Jessica Samuelsson (ORCID: https://orcid.org/0000-0002-8891-6720)
- Konstantinos Poulakis (ORCID: https://orcid.org/0000-0002-6600-8086)
- Anna Marseglia (ORCID: https://orcid.org/0000-0002-9672-6978)
- Silke Kern (ORCID: https://orcid.org/0000-0001-7617-7214)
- Eric Westman (ORCID: https://orcid.org/0000-0002-3115-2977)
- Johan Skoog (ORCID: https://orcid.org/0000-0001-9549-5875)
- Therese Rydberg Sterner (ORCID: https://orcid.org/0000-0001-8202-8522)
- Lina Rydén (ORCID: https://orcid.org/0000-0002-3817-2620)
- Rosaleena Mohanty (ORCID: https://orcid.org/0000-0001-6499-1251)
Institutions
- Wellcome Centre for Human Neuroimaging (GB)
- King's College London (GB)
- Sahlgrenska University Hospital (SE)
- Karolinska Institutet (SE)
- Region Västra Götaland (SE)
- McGill Genome Centre (CA)
- McGill University (CA)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1002/alz.14435
- Citations
- 15
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 5.78
Funders
- Stiftelsen för Gamla Tjänarinnor
- Svenska Sällskapet för Medicinsk Forskning
- Hjärnfonden
- Karolinska Institutet
- Stiftelsen Olle Engkvist Byggmästare
- Vetenskapsrådet
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- David och Astrid Hageléns Stiftelse
- Demensfonden
- Center for Innovative Medicine