[Uncommon Yet Severe: Metabolic Acidosis from Concurrent Use of Paracetamol and Flucloxacillin].
A 60-year-old polymorbid patient developed severe metabolic acidosis during weeks of treatment with flucloxacillin and paracetamol. The acidosis was triggered by an accumulation of 5-oxoproline due to pre-existing risk factors for glutathione deficiency as well as a ketoacidosis due to starvation. After treatment with N-acetylcysteine and hemofiltration, the acidosis completely resolved.
Authors
- Patrick R. Bader (ORCID: https://orcid.org/0000-0002-9663-9962)
- N Todorov
Institutions
- University of Zurich (CH)
- Nizhny Novgorod Institute of Management and Business (RU)
Publication Details
- Journal
- PubMed
- Published
- 2024-12-01
- DOI
- https://doi.org/10.23785/praxis.2024.11.008
- Citations
- 1
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.38