AMPK-mTOR pathway modulates glycolysis reprogramming in unexplained recurrent spontaneous abortion
Our research had illustrated that AMPK-mTOR pathway regulated glycolysis reprogramming and improved the pregnancy outcomes of URSA. Furthormore, Met and 2-DG promoted the differentiation of CD4<sup>+</sup> T cells into Treg cells, providing theoretical basis for clinical prevention of URSA.
Authors
- Bei Gan
- Lianwen Jin (ORCID: https://orcid.org/0000-0002-5456-0957)
- Xiumei Zhao
- Yihong Chen (ORCID: https://orcid.org/0000-0002-7085-199X)
- Shan Zheng (ORCID: https://orcid.org/0000-0002-5853-9717)
- Juanbing Wei (ORCID: https://orcid.org/0000-0002-7589-1130)
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- BMC Pregnancy and Childbirth
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s12884-024-07054-1
- Citations
- 5
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 1.20
Funders
- Natural Science Foundation of Fujian Province