Optimal Cutoff Values and Utility of High-Sensitivity Troponin T and NT-proBNP for the Risk Stratification of Patients with Acute Pulmonary Embolism
We identified an optimal cutoff of 46 ng/L for hsTnT and 1092 pg/mL for NT-proBNP, though the AUC for both markers suggests low to moderate performance for the risk stratification of initially hemodynamically stable PERT patients. Use of these biomarkers to risk stratify PE may require reconsideration.
Authors
- Eun Sang Lee (ORCID: https://orcid.org/0000-0002-8506-1579)
- Savanah Harshbarger
- William B. Stubblefield (ORCID: https://orcid.org/0000-0003-3817-1414)
- Christopher Kabrhel (ORCID: https://orcid.org/0000-0002-8699-7176)
- Karsten Stannek
- Nora Horick (ORCID: https://orcid.org/0000-0002-4355-5853)
- Jesse O. Wrenn (ORCID: https://orcid.org/0000-0002-9869-9328)
- Drew A. Birrenkott (ORCID: https://orcid.org/0000-0001-6962-0273)
- Christiana K Prucnal (ORCID: https://orcid.org/0000-0001-5540-5601)
- Gregory Andrew Peters (ORCID: https://orcid.org/0000-0003-0026-9985)
- Grace Wang (ORCID: https://orcid.org/0000-0003-2063-031X)
- Kyle Chang (ORCID: https://orcid.org/0009-0005-5931-3567)
- Tim Matthews (ORCID: https://orcid.org/0009-0005-5157-9010)
- Isabel Dhar
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Clinical Chemistry
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1093/clinchem/hvae212
- Citations
- 4
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 2.20