Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade
Osthole ameliorates wear particle-induced osteogenic impairment by mitigating endoplasmic reticulum stress via PERK signaling cascade. These findings suggest that OST may serve as a potential therapeutic agent for combating wear particle-induced osteogenic impairment, offering a novel alternative strategy for managing aseptic prosthesis loosening.
Authors
- Qi Wu (ORCID: https://orcid.org/0000-0003-1129-2865)
- Nirong Bao (ORCID: https://orcid.org/0000-0003-3048-714X)
- Yongjie Wu (ORCID: https://orcid.org/0000-0002-0297-2319)
- Jianlun Hu
- Zhengrong Ren
- Juan Jiang (ORCID: https://orcid.org/0000-0002-4484-0744)
- Bin Chen (ORCID: https://orcid.org/0000-0002-9997-9428)
- Jianning Zhao (ORCID: https://orcid.org/0000-0001-9454-409X)
- Hao Ding (ORCID: https://orcid.org/0000-0003-0774-4670)
- Li Cheng (ORCID: https://orcid.org/0000-0001-8984-0812)
- Hui Jiang (ORCID: https://orcid.org/0000-0002-8448-1707)
- Tao Yuan (ORCID: https://orcid.org/0000-0001-7542-3057)
- Xin Yu (ORCID: https://orcid.org/0000-0003-0676-7256)
- Fang Peng (ORCID: https://orcid.org/0000-0002-8684-2756)
- Jia Meng (ORCID: https://orcid.org/0009-0003-6583-4233)
- Ziying Sun
- Dongsheng Wang
- Yang Wang (ORCID: https://orcid.org/0000-0002-5040-2492)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Army Medical University (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- Daping Hospital (CN)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Beijing Tsinghua Chang Gung Hospital (CN)
- State Key Laboratory of Pharmaceutical Biotechnology
- Nanjing University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1186/s10020-024-01034-z
- Citations
- 1
- Primary Topic
- Orthopaedic implants and arthroplasty
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- National Natural Science Foundation of China
- Nanjing University