NaHCO3 modulates the <i>bla</i> operon and β-lactam susceptibility in borderline oxacillin-resistant <i>Staphylococcus aureus</i> (BORSA)
These data demonstrate that NaHCO3 influences expression of genes within the bla operon, translating to reduced β-lactamase production and enhanced β-lactam susceptibility in BORSA strains. Furthermore, this indicates that the classical blaZ regulators, blaI and blaR1, are the likely mediators of NaHCO3-mediated repression of mecA. However, questions still remain regarding the mechanism via which NaHCO3 regulates the bla operon.
Authors
- Arnold S. Bayer (ORCID: https://orcid.org/0000-0003-1968-0192)
- Henry F. Chambers (ORCID: https://orcid.org/0000-0001-5317-4491)
- Richard A. Proctor (ORCID: https://orcid.org/0000-0003-3011-7958)
- Selvi C. Ersoy (ORCID: https://orcid.org/0000-0002-8792-2061)
- Sabrina L. Madrigal
- Yan Q. Xiong (ORCID: https://orcid.org/0000-0002-8732-6948)
Institutions
- University of Wisconsin–Madison (US)
- University of California, Los Angeles (US)
- UCLA Medical Center (US)
- Harbor–UCLA Medical Center (US)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1093/jac/dkae455
- Citations
- 1
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- National Institutes of Health