KLF5 silencing restrains proliferation, invasion, migration and angiogenesis of gallbladder carcinoma cells by transcriptional regulation of PDGFA
Collectively, our results suggest that KLF5 regulates GBC cell proliferation, invasion, migration, angiogenesis, as well as apoptosis, via mediating PDGFA transcriptionally, which might provide a novel therapeutic strategy for treatment of human GBC.
Authors
- Jifeng Nie
- Xiaowei Lu (ORCID: https://orcid.org/0000-0003-3701-7837)
- Dandan Zhang (ORCID: https://orcid.org/0000-0001-5305-9856)
- Xuefeng Yin (ORCID: https://orcid.org/0000-0002-9922-0913)
- Kai Zhao (ORCID: https://orcid.org/0000-0002-4492-6185)
- Kui Hu
Institutions
- Zhejiang Hospital (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2024-12-20
- DOI
- https://doi.org/10.1007/s00432-024-06059-9
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Program of Zhejiang Province