The ENDOMIX project: an interdisciplinary approach to understanding how real-life chemical mixtures target the immune system to trigger disease
<ns3:p> The true impact of endocrine disrupting chemicals (EDCs) on human health is far from being understood. Humans are exposed to mixtures of chemicals throughout their lives, yet regulations and most studies focus on individual chemicals. ENDOMIX takes a novel approach to identifying associations and causality between EDCs and adverse health outcomes by focusing on exposure to mixtures of EDCs over the life course, including windows of susceptibility, using human biomonitoring data from several European cohorts. We will model and measure how real-life EDC mixtures act together and target the immune system to initiate, trigger or maintain disease. Health effects will be investigated using pioneering methodologies ranging from high-throughput <ns3:italic>in vitro</ns3:italic> bioassays, sophisticated organoid and co-culture systems, to <ns3:italic>in vivo</ns3:italic> models. In combination, they will provide valuable information on mechanistic pathways and transgenerational effects of EDC exposure. We aim to identify biomarkers and patterns of chemical exposures that are easy to measure, available for large cohorts and indicative for adverse health outcomes. We will use <ns3:italic>in vitro</ns3:italic> , <ns3:italic>in silico</ns3:italic> and <ns3:italic>in vivo</ns3:italic> data to strengthen causal inference using a weight-of-evidence approach. Moreover, using novel text mining methods, we will create knowledge graphs to capture and summarize the complexity of biomechanistic information, which aids rapid risk assessments and the creation of network models. The knowledge generated by ENDOMIX will provide an evidence base for policy-making and also reach people of all ages to raise awareness of the risks of EDC exposure and encourage health-promoting behaviors. </ns3:p>
Authors
- Jana Klánová (ORCID: https://orcid.org/0000-0002-8818-5307)
- Sophie Langouët (ORCID: https://orcid.org/0000-0002-0016-5425)
- Cécile Chevrier (ORCID: https://orcid.org/0000-0003-3101-8222)
- Beate Isabella Escher (ORCID: https://orcid.org/0000-0002-5304-706X)
- Robert van Vorstenbosch (ORCID: https://orcid.org/0000-0003-1953-0207)
- Oliver Robinson (ORCID: https://orcid.org/0000-0002-4735-0468)
- Marion Ouidir (ORCID: https://orcid.org/0000-0001-6027-1484)
- Tamara Tal (ORCID: https://orcid.org/0000-0001-8365-9385)
- Roel C.H. Vermeulen (ORCID: https://orcid.org/0000-0003-4082-8163)
- Sabrina Llop (ORCID: https://orcid.org/0000-0002-6784-4211)
- Elliott J. Price (ORCID: https://orcid.org/0000-0001-5691-7000)
- Tobias Polte
- Thi Anh Mai Pham (ORCID: https://orcid.org/0000-0001-7963-8864)
- Charline Warembourg (ORCID: https://orcid.org/0000-0003-2716-9167)
- Janine F. Felix (ORCID: https://orcid.org/0000-0002-9801-5774)
- Gunda Herberth (ORCID: https://orcid.org/0000-0003-0212-3509)
- Petra Bořilová Linhartová (ORCID: https://orcid.org/0000-0003-0953-3615)
- Claire Philippat (ORCID: https://orcid.org/0000-0002-4959-6648)
- Georg Braun (ORCID: https://orcid.org/0000-0002-2513-9039)
- Liesbeth Duijts (ORCID: https://orcid.org/0000-0001-6731-9452)
- Kristin Schubert (ORCID: https://orcid.org/0000-0003-4365-084X)
- Mònica Guxens (ORCID: https://orcid.org/0000-0002-8624-0333)
- Normand Podechard (ORCID: https://orcid.org/0000-0002-2638-3180)
- Ana Claudia Zenclussen (ORCID: https://orcid.org/0000-0003-3544-4552)
- Corinne Martin‐Chouly (ORCID: https://orcid.org/0000-0001-7493-0612)
- María-José López-Espinosa (ORCID: https://orcid.org/0000-0003-1202-8740)
- Nicole Meyer (ORCID: https://orcid.org/0000-0002-7990-2175)
- Marie‐Laure Pinel‐Marie (ORCID: https://orcid.org/0000-0001-5128-0741)
- Katharina Krischak
- Anne Schumacher (ORCID: https://orcid.org/0000-0002-6427-3724)
- Yvonne Kohl (ORCID: https://orcid.org/0000-0001-8119-5441)
- Raymond Pieters (ORCID: https://orcid.org/0000-0002-3427-8401)
- Violeta Stojanovska (ORCID: https://orcid.org/0000-0002-5772-2843)
- Léa Maître (ORCID: https://orcid.org/0000-0003-3682-7117)
- Sergio Gómez-Olarte (ORCID: https://orcid.org/0000-0002-9494-068X)
- Albert Braeuning (ORCID: https://orcid.org/0000-0003-3810-027X)
- Dominique Lagadic‐Gossmann (ORCID: https://orcid.org/0000-0002-4888-236X)
- Klara Hilscherová
- Paolo Vineis (ORCID: https://orcid.org/0000-0001-8935-4566)
- Linda Böhmert
- Valentina Belmar Erilkin
Publication Details
- Journal
- Open Research Europe
- Published
- 2024-12-19
- DOI
- https://doi.org/10.12688/openreseurope.19088.1
- Citations
- 2
- Primary Topic
- Effects and risks of endocrine disrupting chemicals
- Type
- article
- Field-Weighted Citation Impact
- 0.63