Endoplasmic Reticulum Stress Induces ROS Production and Activates NLRP3 Inflammasome Via the PERK-CHOP Signaling Pathway in Dry Eye Disease
This study explores the role of ER stress-induced oxidative stress and NLRP3-IL-1β mediated inflammation in DED, and highlights the therapeutic potential of PERK-CHOP axis and TXNIP in the treatment of DED.
Authors
- Zhiwei Zha
- Decheng Xiao (ORCID: https://orcid.org/0000-0002-3047-2979)
- Fangli Peng
- Yang Liu
- Zhenzhen Sun (ORCID: https://orcid.org/0000-0001-9828-7377)
- Zihao Liu (ORCID: https://orcid.org/0000-0003-4044-2172)
- Wei Chen (ORCID: https://orcid.org/0000-0001-6959-7122)
- Xu Shang
Institutions
- Wenzhou Medical University (CN)
- Wuhan University (CN)
- Soochow University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- Zhongnan Hospital of Wuhan University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1167/iovs.65.14.34
- Citations
- 23
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 12.49
Funders
- National Natural Science Foundation of China
- Medical Science and Technology Project of Zhejiang Province