Single-nuclei RNA-sequencing fails to detect molecular dysregulation in the preeclamptic placenta
scRNA-seq has important advantages over snRNA-seq for comprehensive transcriptomics studies of the placenta, especially to understand cell-type resolved dysregulation in pathologies. Yet, to address the dilemma of an underrepresented syncytium, studies benefit from complementary nuclei extraction.
Authors
- Amit Zeisel (ORCID: https://orcid.org/0000-0002-2424-9279)
- Ido Solt (ORCID: https://orcid.org/0000-0002-6717-7631)
- Simcha Yagel (ORCID: https://orcid.org/0000-0002-1412-5862)
- Inbal Admati
- Hannah Hochgerner (ORCID: https://orcid.org/0000-0002-7739-666X)
- Osnat Ophir
- Niv Skarbianskis
Institutions
- Technion – Israel Institute of Technology (IL)
- Hadassah Medical Center (IL)
- Rappaport Family Institute for Research in the Medical Sciences (IL)
Publication Details
- Journal
- Placenta
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1016/j.placenta.2024.12.011
- Citations
- 8
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 4.66