Tumor gene expression is associated with venous thromboembolism in patients with ductal pancreatic adenocarcinoma
Patients with pancreatic cancer and VTE show a different tumor gene expression profile than those without VTE. Multiple coagulation-related genes were differentially expressed in classical versus basal-like molecular subtype, suggesting that there is a difference in pro-thrombotic phenotype.
Authors
- Maarten F. Bijlsma (ORCID: https://orcid.org/0000-0001-6627-3229)
- Marc G. Besselink (ORCID: https://orcid.org/0000-0003-2650-9350)
- Hanneke Wilmink
- Frederike Dijk (ORCID: https://orcid.org/0000-0003-3970-6601)
- Q. Molenaar
- J. Sven D. Mieog (ORCID: https://orcid.org/0000-0002-3649-8504)
- R.G. Hanna-Sawires (ORCID: https://orcid.org/0000-0002-4303-3000)
- Lodewijk A.A. Brosens (ORCID: https://orcid.org/0000-0003-1341-8994)
- Olivier R. Busch (ORCID: https://orcid.org/0000-0001-9605-6831)
- Floris T.M. Bosch (ORCID: https://orcid.org/0000-0002-1286-5402)
- Henri H. Versteeg (ORCID: https://orcid.org/0000-0003-4294-175X)
- Joanne Verheij (ORCID: https://orcid.org/0000-0003-1283-630X)
- Karin A. H. Kaasjager (ORCID: https://orcid.org/0000-0001-6958-8285)
- Bert A. Bonsing (ORCID: https://orcid.org/0000-0003-4513-5737)
- Arantza Fariña Sarasqueta (ORCID: https://orcid.org/0000-0002-4307-1568)
- Frederikus Albertus Klok (ORCID: https://orcid.org/0000-0001-9961-0754)
- Nick van Es (ORCID: https://orcid.org/0000-0001-5256-6346)
- Jeroen T. Buijs (ORCID: https://orcid.org/0000-0001-5816-9739)
- Saskia Briedé (ORCID: https://orcid.org/0000-0002-4673-2667)
- Hans Halfwerk (ORCID: https://orcid.org/0000-0001-5752-0806)
- Jesse V. Groen (ORCID: https://orcid.org/0000-0002-2438-4665)
- Jan Köster (ORCID: https://orcid.org/0000-0002-0890-7585)
Institutions
- Leiden University (NL)
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Thrombosis Research
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1016/j.thromres.2024.109240
- Citations
- 4
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.13
Funders
- AstraZeneca
- Celgene
- ZonMw
- Daiichi-Sankyo
- KWF Kankerbestrijding
- Servier
- Trombosestichting Nederland
- LEO Pharma
- HORIZON EUROPE Framework Programme