Islands of genomic stability in the face of genetically unstable metastatic cancer
Regions of truncal LOH are strongly retained in the presence of genetic instability and, therefore, represent genetic vulnerabilities in pancreatic adenocarcinomas. A CRISPR-based gene therapy approach targeting these regions may be a novel way to genetically target metastatic cancer.
Authors
- Ralph H. Hruban (ORCID: https://orcid.org/0000-0003-4554-5672)
- Sarah J. Wheelan (ORCID: https://orcid.org/0000-0002-9002-0800)
- Kirsten Bowland (ORCID: https://orcid.org/0000-0002-8618-6154)
- Alyza Skaist
- Rachel Karchin (ORCID: https://orcid.org/0000-0002-5069-1239)
- Elizabeth Thompson (ORCID: https://orcid.org/0000-0002-1094-8861)
- Christine A. Iacobuzio–Donahue (ORCID: https://orcid.org/0000-0002-4672-3023)
- Nicholas J. Roberts (ORCID: https://orcid.org/0000-0002-8709-0664)
- Matthew H. Bailey (ORCID: https://orcid.org/0000-0003-4526-9727)
- James R. Eshleman (ORCID: https://orcid.org/0000-0002-9274-8459)
- Jiaying Lai (ORCID: https://orcid.org/0000-0003-3652-1070)
- Selina Shiqing K. Teh (ORCID: https://orcid.org/0000-0002-5281-1978)
- Yan Zhang (ORCID: https://orcid.org/0009-0002-6782-2271)
Institutions
- Brigham Young University (US)
- National Institutes of Health (US)
- Memorial Sloan Kettering Cancer Center (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- National Human Genome Research Institute (US)
- Cancer Research Center (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1371/journal.pone.0298490
- Citations
- 2
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- National Institutes of Health