Technique for Generating Dry Aerosol Particles from a Solution: The Case of Fluconazole

Abstract—Infectious diseases affecting the respiratory system are currently a serious medical problem. One of the ways of increasing the effectiveness of therapy for such diseases is targeted delivery of drugs. This approach requires the development of new methods for generating aerosols of drugs with particle sizes which enable penetrating into specified areas of the respiratory system. In this work, a technique for generating dry aerosol particles based on ultrasonic spraying of a drug solution is suggested and implemented. Using the example of a solution of the medicinal antifungal substance fluconazole, we show that this technique enables generating aerosol particles with stable concentration and average size for more than 2 hours. The resulting aerosol has optimal inhalation parameters: size from 1 to 1.9 microns and concentration of 70 000 ± 6500 cm−3. The suggested technique makes it possible to further study the biological effect of aerosols of drugs.