Reply

We have a few comments in response.Recurrent isolated mast cell-mediated angioedema (AE), despite representing the major cause of idiopathic AE, has thus far received very little specific interest in the literature, and its clinical characteristics have not been very well defined.Recently, a debate has arisen as to whether this recurrent AE should continue to be considered a subtype of chronic spontaneous urticaria (CSU) or a distinct entity.This discussion has been driven by recent studies comparing groups of patients with chronic histaminergic AE (CHA) and AE with CSU (AE-CSU),