Targeting ATM enhances radiation sensitivity of colorectal cancer by potentiating radiation-induced cell death and antitumor immunity
Targeting ATM enhances radiation-induced tumor cell death and boosts antitumor immune responses, offering a promising strategy to overcome CRC radiation resistance. The synergy of radiotherapy, ATM inhibitior, and immune checkpoint blockade highlights a novel therapeutic approach for CRC management.
Authors
- Yifan Zou (ORCID: https://orcid.org/0000-0002-5876-9766)
- Yi� Ding (ORCID: https://orcid.org/0000-0001-5035-9255)
- Zhenkang Li
- Yuwen Xie
- Yuan Fang (ORCID: https://orcid.org/0000-0003-3903-6011)
- Yilin Zheng
- Yaowei Zhang (ORCID: https://orcid.org/0000-0001-7756-6756)
- Yizhi Zhan (ORCID: https://orcid.org/0000-0002-5079-6129)
- Mingdao Lin (ORCID: https://orcid.org/0000-0002-0277-6852)
- Yang Liu (ORCID: https://orcid.org/0000-0002-5058-7781)
- Zhiyong Shen (ORCID: https://orcid.org/0000-0002-6155-4598)
- Shengqi Yin
Institutions
- Nanfang Hospital (CN)
- Zhujiang Hospital (CN)
- Hainan General Hospital (CN)
- Southern Medical University (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1016/j.jare.2024.12.023
- Citations
- 17
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.97
Funders
- National Natural Science Foundation of China
- Southern Medical University
- Nanfang Hospital