Quantification of safe operation conditions for large-area platinum-iridium electrodes in neurostimulation application

Residual voltage plays a greater role concerning reversibility in prolonged stimulation and charge imbalance of applied biphasic current pulses. The Ema saturation is suggested as a new marker for the occurrence of irreversible reactions which needs further investigation. Current amplitudes of 1 mA for the considered single electrode configuration did not lead to a capacitive voltage saturation nor a considerable dissolution of platinum ions and is thus considered as a safe operation configuration.