Virological and Immunological Characteristics of <scp>HBeAg</scp> ‐Positive Chronic Hepatitis B Patients With Low <scp>HBsAg</scp> Levels
HBeAg-positive CHB patients with low HBsAg and genotype C exhibited higher noninvasive fibrosis indexes compared with typical patients, accompanied by a significant increase in quasispecies variants associated with preS2 deletion. The emergence of the preS2 deletion mutants in patients could be due to its enhanced ability to evade the host immunity.
Authors
- Rui Huang (ORCID: https://orcid.org/0000-0002-3189-7960)
- Chao Wu (ORCID: https://orcid.org/0000-0002-1657-010X)
- Quan Zhang (ORCID: https://orcid.org/0000-0001-9112-0662)
- Ming Li (ORCID: https://orcid.org/0000-0001-8882-6613)
- Yuxin Chen (ORCID: https://orcid.org/0000-0001-5955-687X)
- Jian Wang (ORCID: https://orcid.org/0000-0001-7620-6740)
- Yong Liu (ORCID: https://orcid.org/0000-0002-8420-7302)
- Jiaqi Gu (ORCID: https://orcid.org/0000-0002-5304-1688)
- Guiyang Wang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1111/apt.18448
- Citations
- 5
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.93
Funders
- National Science Foundation
- Nanjing University
- Nanjing Drum Tower Hospital
- National Key Research and Development Program of China