Effects of cardiac contractility modulation on autophagy and apoptosis of cardiac myocytes in rabbits with chronic heart failure
The intervention of CCM has been shown to enhance both myocardial systolic and diastolic function in rabbits with CHF. The mechanism may be related to the inhibition of cardiomyocyte autophagy by regulating the expression levels of Beclin1, P62, and LC3B(II/I) in cardiomyocytes, as well as the reversal of cardiomyocyte apoptosis by regulating the expression levels of Bcl-2, ALDH2, Bax, and Caspase-3 in cardiomyocytes.
Authors
- H Liu (ORCID: https://orcid.org/0009-0005-5752-4360)
- Qingqing Hao
- Shi-Lin Lv (ORCID: https://orcid.org/0009-0009-2747-8171)
- Jing Zhang (ORCID: https://orcid.org/0009-0001-5370-0014)
Institutions
- Hebei Medical University (CN)
- Hebei North University (CN)
- Hebei General Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1371/journal.pone.0306242
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00