Pharmacokinetics, bioavailability, and tissue distribution of MRTX1133 in rats using UHPLC-MS/MS
MRTX1133 was quickly absorbed, and widely distributed in the main organs. This study provided a reference for the quantitative determination of MTRX1133 in preclinical or clinical trials.
Authors
- Wanying Shen (ORCID: https://orcid.org/0009-0007-6399-8022)
- Lei Pan
- Yuan Zhou (ORCID: https://orcid.org/0000-0003-2892-0100)
- Meng Pan
- Yijun Tang (ORCID: https://orcid.org/0000-0002-8202-7084)
- Wei Lu (ORCID: https://orcid.org/0000-0003-0290-4356)
- Huijuan Tang (ORCID: https://orcid.org/0000-0002-3589-4943)
- Rong Zeng (ORCID: https://orcid.org/0009-0007-2908-4809)
Institutions
- Hubei University of Medicine (CN)
- Huazhong Agricultural University (CN)
- Hubei University of Chinese Medicine (CN)
- Wuhan University (CN)
- Taihe Hospital (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.3389/fphar.2024.1509319
- Citations
- 4
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.94