Gut virome dysbiosis impairs antitumor immunity and reduces 5-fluorouracil treatment efficacy for colorectal cancer
These findings suggest the importance of maintaining gut virome integrity or activating TLR3 as adjunct strategies to enhance chemotherapy outcomes in CRC patients.
Authors
- Qiurong Wang
- Ying Yang (ORCID: https://orcid.org/0000-0001-6327-631X)
- Hui Huang (ORCID: https://orcid.org/0009-0009-2136-3517)
- Biao Wen
- Wei Zhong
- Xiaowen Yang (ORCID: https://orcid.org/0000-0003-0955-4977)
- Feng He (ORCID: https://orcid.org/0000-0001-7114-8078)
- Xiaojiao Wang (ORCID: https://orcid.org/0009-0005-0649-9003)
- Jun Li (ORCID: https://orcid.org/0009-0004-1683-5130)
Institutions
- Chengdu Medical College (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
- Chengdu Fifth People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.3389/fonc.2024.1501981
- Citations
- 6
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Chengdu Medical College
- Department of Science and Technology of Sichuan Province
- Natural Science Foundation of Sichuan Province
- Health Commission of Sichuan Province