Identification and validation of the diagnostic biomarker MFAP5 for CAVD with type 2 diabetes by bioinformatics analysis
In this study, a multi-omics approach was used to identify 10 CAVD-related biomarkers (COL5A1, COL5A2, THBS2, MFAP5, BTG2, COL1A1, COL1A2, MXRA5, LUM, CD34) and to develop an exploratory risk model. Western blot (WB) and immunofluorescence experiments revealed that MFAP5 plays a crucial role in the progression of CAVD in the context of diabetes, offering new insights into the disease mechanism.
Authors
- Xingyu Qian
- Qiang Shen (ORCID: https://orcid.org/0000-0002-1491-5434)
- Fuqiang Tong (ORCID: https://orcid.org/0000-0002-0470-6698)
- Jiawei Shi
- Dingyi Yao
- Zhengfeng Fan (ORCID: https://orcid.org/0000-0003-0772-4434)
- Chao Zhang
- Chen Jiang (ORCID: https://orcid.org/0000-0002-2983-7512)
- Nianguo Dong (ORCID: https://orcid.org/0000-0002-8424-1703)
- Zongtao Liu (ORCID: https://orcid.org/0000-0001-7936-4752)
- Fan Lin (ORCID: https://orcid.org/0009-0003-2210-6279)
Institutions
- Union Hospital (HK)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.3389/fimmu.2024.1506663
- Citations
- 2
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China