EVALUATION OF SOME HAEMATOLOGICAL AND BIOCHEMICAL PARAMETERS IN PATIENTS INFECTED WITH HELICOBACTER PYLORI ATTENDING IMO STATE SPECIALIST HOSPITAL, OWERRI

Helicobacter pylori is a bacterium that causes peptic ulcer disease. This study was aimed at determining the levels of some haematological parameters and biochemical parameters of patients infected with Helicobacter pylori attending Imo State Specialist, Hospital Umuguma, Owerri. A cross-sectional study was carried out from the month of June to August, 2023 and all eligible subjects who filled the questionnaire and gave a written informed consent for the study were sampled. The study population consisted of 50 H. pylori infected patients and an equivalent number of aged - matched healthy subjects, who served as the controls. Blood samples were collected from the participants and analysed for PCV using micro haematocrit method, Red blood cell counts using Thoma (manual counting) method, serum iron (Ferrozine method) and amylase using enzymatic method. The results of the tests were analyzed using SPSS version 21.The mean values of PCV (31.36±3.53)%, RBC (3.93±4.69)x1012/L and serum iron (48.22±19.66)μg/dl were significantly reduced in H. pylori infected individual when compared to controls (36.10±3.37)%, (5.25±7.13)x1012/L and (79.16±19.32), μg/dl (p=0.000). The mean value of amylase (95.15±34.88) U/L was significantly increased in H. pylori infected individuals when compared to controls (52.92±11.44) U/L. There was no significant difference in the mean values of PCV (32.29±3.49)%, RBC (3.76±3.71) x109/L, Iron (45.18±17.59) μg/dl and Amylase (99.28±37.86)U/L in male H. pylori infected individuals when compared to the females. (30.50±3.40)%, (4.08±5.51) x109/L, (51.04±21.35) μg/dl and (91.35±32.15) U/L t=1.83, (p=0.073, t=1.06, p=0.297, t=0.80, p=0.427, t= 0.23, and p=0.818. H.pylori infection leads to a decline in packed cell volume, RBC and serum iron levels and an increase in amylase. Gender difference does not have an effect on PCV, RBC, iron and amylase levels in H. Pylori infection.