The Formyl Peptid Receptor Ligand Ac2-26 Improves the Integrity of the Blood−Brain Barrier in the Course of Pneumococcal Meningitis
This study extends previous findings on the anti-inflammatory properties of Ac2-26 by demonstrating that Ac2-26 positively affects BBB integrity via FPR2 during pneumococcal meningitis. These findings suggest that further investigation of Ac2-26 and other FPR modulators as potential therapies for <i>Streptococcus pneumoniae</i>-induced meningitis is warranted.
Authors
- Simone C. Tauber (ORCID: https://orcid.org/0000-0001-9149-3071)
- Markus Kipp (ORCID: https://orcid.org/0000-0001-5043-9052)
- Jochen Karl Rössler (ORCID: https://orcid.org/0000-0003-4022-4917)
- Lars‐Ove Brandenburg (ORCID: https://orcid.org/0000-0002-6126-8153)
- Johannes Deutloff
- Irina Pöhner
Institutions
- Universitätsklinikum Aachen (DE)
- University of Rostock (DE)
- RWTH Aachen University (DE)
Publication Details
- Journal
- Cells
- Published
- 2024-12-19
- DOI
- https://doi.org/10.3390/cells13242104
- Citations
- 2
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Deutsche Forschungsgemeinschaft