Impact of Immobilization Method on DNA Stretching Characteristics

The problem of stretching a flexible polymer with given conditions at the ends, under the action of a fixed force, is considered. A mathematical model is constructed for different energy functions describing the elasticity of the polymer and different immobilization methods. It is shown that the dependence of stretching on the polymer length is linear. Numerical results are given. The results obtained allow to improve the analysis of experimental data on polymer stretching. The theory offers several verifiable predictions, and experimental methods are proposed to improve the accuracy of measurements.

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Publication Details

Journal
Биофизика
Published
2024-12-15
DOI
https://doi.org/10.31857/s0006302924060021
Primary Topic
DNA and Nucleic Acid Chemistry
Type
article
Field-Weighted Citation Impact
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article

Impact of Immobilization Method on DNA Stretching Characteristics

M. A. Didin
Биофизика
DNA and Nucleic Acid Chemistry
article

Impact of Immobilization Method on DNA Stretching Characteristics

M. A. Didin
article en

Abstract

The problem of stretching a flexible polymer with given conditions at the ends, under the action of a fixed force, is considered. A mathematical model is constructed for different energy functions describing the elasticity of the polymer and different immobilization methods. It is shown that the dependence of stretching on the polymer length is linear. Numerical results are given. The results obtained allow to improve the analysis of experimental data on polymer stretching. The theory offers several verifiable predictions, and experimental methods are proposed to improve the accuracy of measurements.

БиофизикаVol. 69(6)
Moscow Institute of Physics and Technology (RU)
Affordable and clean energy
Openalex Percentile: Top 79%
DNA and Nucleic Acid Chemistry
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