The Action of Dinitrosyl Iron Complexes with a Ligand Based on N-acethyl-L-cysteine upon Inhalation Delivery of These Complexes to Rats
The objective of the present research was to study the action of dinitrosyl iron complexes (DNIC) with a ligand based on N-acetyl-L-cysteine upon long-term inhalation exposure of rats to this substance. It has been shown that as a result, NO stabilized forms pass efficiently through the alveolal membrane into the lung tissue leading to the accumulation of dinitrosyl iron complexes with protein ligands and to an increase in the total NO level in the lungs and other organs thereby inducing a significant and long-lasting hypotensive effect.
Authors
- К. Б. Шумаев (ORCID: https://orcid.org/0000-0001-8835-5188)
- E. K. Ruuge (ORCID: https://orcid.org/0000-0002-0955-3985)
- A. A. Timoshin (ORCID: https://orcid.org/0000-0002-9688-8037)
- A. A. Abramov (ORCID: https://orcid.org/0000-0001-5113-0954)
- V. L. Lakomkin
Institutions
- Russian Academy of Sciences (RU)
- Lomonosov Moscow State University (RU)
- A N Bach Institute of Biochemistry (RU)
- Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences (RU)
- National Medical Research Center of Cardiology (RU)
- Moscow State University (TJ)
Publication Details
- Journal
- Биофизика
- Published
- 2024-12-15
- DOI
- https://doi.org/10.31857/s0006302924060181
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00