Infiltrating macrophages and interferon gamma rather than renal genotype dictate heightened crescentic glomerulonephritis
Using renal transplantation between 129x1/svJ and C57BL/6J mice and anti-GBM disease induction, we found infiltrating immune cells, not intrinsic renal cells, to play the dominant role in initialing and driving glomerular crescent formation. In particular, macrophage IFN-γ expression was critical for crescent formation.
Authors
- Xin Zhou (ORCID: https://orcid.org/0000-0002-5026-8959)
- Quan‐Zhen Li (ORCID: https://orcid.org/0000-0002-7257-0489)
- Yong Du (ORCID: https://orcid.org/0000-0003-1687-9024)
- Chandra Mohan (ORCID: https://orcid.org/0000-0002-1495-7132)
- Yuyang Fu
- V. Kamala
- Dugyala Poojitha
- Yuyang Gao
Institutions
- Pennsylvania State University (US)
- University of Houston (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.3389/fimmu.2024.1484525
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00