Association between Alzheimer's disease pathologic products and age and a pathologic product-based diagnostic model for Alzheimer's disease
In a novel finding, we observed that Tau protein and Aβ had opposite trends with age in both the AD and non-AD groups. The linear regression curves of the AD and non-AD groups had completely opposite trends. Through a machine learning approach, we constructed an AD diagnostic model with excellent performance based on the selected features.
Authors
- Leian Chen (ORCID: https://orcid.org/0000-0002-3640-2090)
- Hongjun Zhen
- Zhi Zhou (ORCID: https://orcid.org/0000-0002-3861-5911)
- Yuye Wang (ORCID: https://orcid.org/0000-0003-2803-2509)
- Weizhe Zhen
- Dantao Peng (ORCID: https://orcid.org/0000-0001-8038-3192)
- Yu Wang (ORCID: https://orcid.org/0000-0001-7988-2007)
- Jiali Zhang (ORCID: https://orcid.org/0000-0003-3052-5329)
- Yu Sun (ORCID: https://orcid.org/0009-0006-2180-3023)
- Wen Shao (ORCID: https://orcid.org/0000-0002-2922-4118)
- Yanan Qiao (ORCID: https://orcid.org/0000-0002-9542-7845)
- Shuhong Jia
- Weihe Zhang (ORCID: https://orcid.org/0009-0008-6392-5664)
Institutions
- Handan College (CN)
- Beijing University of Chinese Medicine (CN)
- China-Japan Friendship Hospital (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2024-12-19
- DOI
- https://doi.org/10.3389/fnagi.2024.1513930
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.39
Funders
- Beijing University of Chinese Medicine
- National Key Research and Development Program of China