Identification of t(X;1)(q28;q21) generating a novel GATAD2B::MTCP1 gene fusion in CMML and its persistence during progression to AML
We propose that the <i>GATAD2B::MTCP1</i> fusion upregulates <i>MTCP1</i> expression rather than generating a fusion protein, thereby contributing to transformation and relapse in AML. Further investigations are needed to elucidate the precise role of this fusion event in myeloid malignancies.
Authors
- Qian Wang (ORCID: https://orcid.org/0000-0003-0900-2806)
- Yiyan Zhu
- Suning Chen (ORCID: https://orcid.org/0000-0001-6294-972X)
- Fenghong Zhang
- Yu Chen (ORCID: https://orcid.org/0000-0001-9933-8869)
- Zhi‐yu Zhang (ORCID: https://orcid.org/0000-0003-1438-6410)
- Chun-xiao Hou
- Yi-zi Liu
Institutions
- Wannan Medical College (CN)
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Hematology
- Published
- 2024-12-18
- DOI
- https://doi.org/10.1080/16078454.2024.2439110
- Citations
- 1
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.45
Funders
- Department of Haematology, Christian Medical College, Vellore