Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors
Overall, these pharmacological experiments underscore an essential role of microglia-expressed A<sub>2A</sub>R with in PVT in pain sensation while revealing a novel analgesic action independent of opioid and cannabinoids receptors. Thus, these findings highlight PVT microglial adenosine A<sub>2A</sub> receptor as a promising target for novel approaches to pain modulation and future analgesic development.
Authors
- Moruo Zhang
- Ran Ji (ORCID: https://orcid.org/0000-0001-5797-0153)
- Yiping Cao (ORCID: https://orcid.org/0000-0003-0388-609X)
- Lingzhen Song (ORCID: https://orcid.org/0000-0001-8768-1256)
- Hong‐Xing Zhang (ORCID: https://orcid.org/0000-0001-5334-733X)
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.3389/fphar.2024.1467305
- Citations
- 4
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Xuzhou Medical University