Progressive iron overload in middle-aged mice impairs olfactory function, triggers lipid oxidation and induces apoptosis
Chronic iron overload leads to progressive oxidative damage, mitochondrial dysfunction, and apoptosis in the olfactory bulb, causing sensory deficits. Targeting iron accumulation and oxidative damage may offer new strategies for early intervention in neurodegenerative diseases, highlighting the importance of addressing iron dysregulation.
Authors
- Hongping Wang (ORCID: https://orcid.org/0000-0002-0397-413X)
- Zongliang Xiong (ORCID: https://orcid.org/0000-0001-5529-6951)
- Zhengli Chen (ORCID: https://orcid.org/0000-0002-9850-528X)
- Yucong Liu (ORCID: https://orcid.org/0000-0002-3753-9670)
- Lanlan Jia
- Lin Deng (ORCID: https://orcid.org/0000-0001-9120-2289)
- Riyi Shi (ORCID: https://orcid.org/0000-0002-7297-9428)
- Lu Zhao (ORCID: https://orcid.org/0000-0002-8055-5211)
- Chao Huang (ORCID: https://orcid.org/0000-0002-1521-5739)
- Yao Wang
- Qihui Luo (ORCID: https://orcid.org/0000-0002-5561-2456)
Institutions
- Purdue University West Lafayette (US)
- Sichuan Agricultural University (CN)
- Sichuan Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.3389/fphar.2024.1506944
- Citations
- 4
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.44