Poor prognostic factors for relapse of interstitial lung disease in microscopic polyangiitis: the Japanese multicentre REVEAL cohort study
The initial serum high KL-6 and SP-D levels and the prevalence of the UIP pattern were associated with ILD relapse in patients with MPA-ILD. Our multicentre cohort study indicated that the KSU model, which consists of KL-6 ≥ 430 U/mL, SP-D ≥ 89.5 ng/mL, and the presence of the UIP pattern, is a useful predictor of ILD relapse in patients with MPA after immunosuppressive therapy.
Authors
- Keiichiro Kadoba (ORCID: https://orcid.org/0000-0002-8242-9374)
- Shogo Matsuda (ORCID: https://orcid.org/0000-0003-0023-3616)
- Tsuneyasu Yoshida (ORCID: https://orcid.org/0000-0003-3114-8959)
- Motomu Hashimoto (ORCID: https://orcid.org/0000-0002-9241-060X)
- Tohru Takeuchi (ORCID: https://orcid.org/0000-0002-0065-929X)
- Tomoki Taniguchi (ORCID: https://orcid.org/0000-0003-0244-6826)
- Ryosuke Hiwa (ORCID: https://orcid.org/0000-0001-6968-5712)
- Mayu Shiomi (ORCID: https://orcid.org/0009-0008-8992-1805)
- Ayana Okazaki
- Takuya Kotani (ORCID: https://orcid.org/0000-0003-2190-0780)
- Daisuke Nishioka (ORCID: https://orcid.org/0000-0002-3116-1195)
- Wataru Yamamoto (ORCID: https://orcid.org/0000-0002-0810-4221)
- Ryu Watanabe (ORCID: https://orcid.org/0000-0002-1089-5296)
- Atsushi Manabe (ORCID: https://orcid.org/0000-0002-3264-8261)
- Yuichi Masuda
Institutions
- Kyoto University (JP)
- Kurashiki Central Hospital (JP)
- Osaka Metropolitan University (JP)
- Tokyo Metropolitan University (JP)
- Osaka University of Pharmaceutical Sciences (JP)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s13075-024-03453-z
- Citations
- 2
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.84