Dissecting the functions and regulatory mechanisms of disulfidoptosis-related RPN1 in pan-cancer: modulation of immune microenvironment and cellular senescence
These findings highlight RPN1 as a key pan-cancer regulator, influencing immune microenvironment interactions and cellular senescence. The regulation of disulfidoptosis by RPN1 presents a promising avenue for therapeutic intervention. Targeting RPN1 could enhance immunotherapy efficacy and help mitigate tumor progression, offering a potential strategy for cancer treatment.
Authors
- Jianxiang Li (ORCID: https://orcid.org/0000-0001-6674-7703)
- Lexin Qin
- Xinyu Zhu (ORCID: https://orcid.org/0000-0003-2589-2300)
- Wentao Hu (ORCID: https://orcid.org/0000-0001-8495-4175)
- Xiangrong Song
- Hailong Zhang (ORCID: https://orcid.org/0000-0002-8720-2734)
- Yaoyu Hu (ORCID: https://orcid.org/0000-0001-5510-442X)
- Tingting Liang (ORCID: https://orcid.org/0000-0003-1370-3672)
- Xian Gong
- Meidan Wei
- Jin Wang
Institutions
- Soochow University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.3389/fimmu.2024.1512445
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Ministry of Education, India