Scutellaria barbata D.Don and Hedyotis diffusa Willd herb pair combined with cisplatin synergistically inhibits ovarian cancer progression through modulating oxidative stress via NRF2-FTH1 autophagic degradation pathway
Our findings uncover a synergistic effect of SB-HD and DDP against OC through modulating oxidative stress via NRF2-FTH1 autophagic degradation pathway, which may provide an important theoretical foundation for the use of SB-HD and a new strategy for enhancing DDP chemosensitivity as well as reducing toxic side effects.
Authors
- Xue Sui
- Liu Zhang (ORCID: https://orcid.org/0000-0003-3721-0071)
- Lin Zhang (ORCID: https://orcid.org/0000-0002-5977-6589)
- Yanmin Wang (ORCID: https://orcid.org/0009-0005-2928-9818)
- Min Liu (ORCID: https://orcid.org/0000-0002-2665-0584)
- Chunlin Zhou (ORCID: https://orcid.org/0000-0002-3297-5879)
- Junnan Ma
- Baicheng Gao
- Xingchen Wu (ORCID: https://orcid.org/0009-0005-8194-4939)
Institutions
- Dalian Medical University (CN)
- Dali Traditional Chinese Medicine Hospital (CN)
- Anhui Xinhua University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2024-12-19
- DOI
- https://doi.org/10.1186/s13048-024-01570-6
- Citations
- 5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Liaoning Province