The development of murine bone marrow-derived mast cells expressing functional human MRGPRX2 for ex vivo and in vivo studies
Replacing mouse MrgprB2 with functional human MRGPRX2 in primary BMMCs and their engraftment in MC-deficient mice demonstrated the expression of this receptor in different tissues, which provides unique opportunities to study receptor signaling <i>ex vivo</i> and disease phenotype <i>in vivo.</i>
Authors
- Saptarshi Roy (ORCID: https://orcid.org/0000-0002-4649-0741)
- Maram Bawazir (ORCID: https://orcid.org/0000-0002-9326-1351)
- Hydar Ali (ORCID: https://orcid.org/0000-0001-9190-1960)
Institutions
- King Abdulaziz University (SA)
- University of Pennsylvania (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-19
- DOI
- https://doi.org/10.3389/fimmu.2024.1523393
- Citations
- 2
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.48
Funders
- University of Pennsylvania